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Monitor Carefully (1)pentobarbital will lower the level or influence of fentanyl transmucosal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Carefully. Coadministration of fentanyl with CYP3A4 inducers could lead to your minimize in fentanyl plasma concentrations, deficiency of efficacy or, perhaps, progress of the w